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Phospholipase C-γ1 Is Involved in Signaling the Activation by High NaCl of the Osmoprotective Transcription Factor TonEBP/OREBP

High NaCl elevates activity of the osmoprotective transcription factor TonEBP/OREBP by increasing its phosphorylation, transactivating activity, and localization to the nucleus. We investigated the possible role in this activation of phospholipase C-γ1 (PLC-γ1), which has a predicted binding... Full description

1st Person: Irarrazabal, Carlos E.
Additional Persons: Gallazzini, Morgan; Schnetz, Michael P.; Kunin, Margarita; Simons, Brigitte L.; Williams, Chester K.; Burg, Maurice B.; Ferraris, Joan D.
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 107, No. 2 (2010), p. 906-911
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Type of Publication: Article
Language: English
Published: 2010
Keywords: hypertonicity
phosphorylation
proteomics
Online: Volltext
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