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The Relationship Between Synthetic and Editing Functions of the Active Site of an Aminoacyl-tRNA Synthetase

We have analyzed, by site-directed mutagenesis, the molecular basis of the editing function and its relation to the synthetic function of Escherichia coli methionyl-tRNA synthetase. The data obtained fit a model of the active site that partitions an amino acid substrate between synthetic and... Full description

1st Person: Kim, Hae Yeong
Additional Persons: Ghosh, Gourisankar verfasserin; Schulman, LaDonne H. verfasserin; Brunie, Simone verfasserin; Jakubowski, Hieronim verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 90, No. 24 (1993), p. 11553-11557
More Articles
Type of Publication: Article
Language: English
Published: 1993
Keywords: research-article
Biochemistry
Proofreading
Translation Accuracy
Methionyl-tRNA Synthetase
Structure-Function Relationship
S-Methylhomocysteine Thiolactone
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