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Down Regulation of Specific Binding of [20-3H]Phorbol 12, 13-dibutyrate and Phorbol Ester-Induced Differentiation of Human Promyelocytic Leukemia Cells

Binding of [20-3H]phorbol 12, 13-dibutyrate ([3H]PDB) to intact human promyelocytic leukemia cells susceptible (HL-60) or resistant (R-35) to phorbol ester-induced differentiation was characterized. Specific binding of [3H]PDB to both HL-60 and R-35 cells at 37 degrees C reached a maximum within... Full description

1st Person: Solanki, Virendra
Additional Persons: Slaga, Thomas J. verfasserin; Callaham, Michael verfasserin; Huberman, Eliezer verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 78, No. 3 (1981), p. 1722-1725
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Type of Publication: Article
Language: English
Published: 1981
Keywords: research-article
Cell Biology
HL-60 Cells
Lysozyme Activity
Tumor Promoters
Binding Sites
Online: Volltext
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