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Angiopoietins 3 and 4: Diverging Gene Counterparts in Mice and Humans

The angiopoietins have recently joined the members of the vascular endothelial growth factor family as the only known growth factors largely specific for vascular endothelium. The angiopoietins include a naturally occurring agonist, angiopoietin-1, as well as a naturally occurring antagonist,... Full description

1st Person: Valenzuela, David M.
Additional Persons: Griffiths, Jennifer A. verfasserin; Rojas, Jose verfasserin; Aldrich, Thomas H. verfasserin; Jones, Pamela F. verfasserin; Zhou, Hao verfasserin; McClain, Joyce verfasserin; Copeland, Neal G. verfasserin; Gilbert, Debra J. verfasserin; Jenkins, Nancy A. verfasserin; Huang, Tammy verfasserin; Papadopoulos, Nick verfasserin; Maisonpierre, Peter C. verfasserin; Davis, Samuel verfasserin; Yancopoulos, George D. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 96, No. 5 (1999), p. 1904-1909
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Type of Publication: Article
Language: English
Published: 1999
Keywords: research-article
Biochemistry
Online: Volltext
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024 8 |a 46986 
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100 1 |a Valenzuela, David M. 
245 1 0 |a Angiopoietins 3 and 4: Diverging Gene Counterparts in Mice and Humans  |h Elektronische Ressource 
300 |a Online-Ressource 
500 |a Copyright: Copyright 1993-1999 The National Academy of Sciences of the United States of America 
520 |a The angiopoietins have recently joined the members of the vascular endothelial growth factor family as the only known growth factors largely specific for vascular endothelium. The angiopoietins include a naturally occurring agonist, angiopoietin-1, as well as a naturally occurring antagonist, angiopoietin-2, both of which act by means of the Tie2 receptor. We now report our attempts to use homology-based cloning approaches to identify new members of the angiopoietin family. These efforts have led to the identification of two new angiopoietins, angiopoietin-3 in mouse and angiopoietin-4 in human; we have also identified several more distantly related sequences that do not seem to be true angiopoietins, in that they do not bind to the Tie receptors. Although angiopoietin-3 and angiopoietin-4 are strikingly more structurally diverged from each other than are the mouse and human versions of angiopoietin-1 and angiopoietin-2, they appear to represent the mouse and human counterparts of the same gene locus, as revealed in our chromosomal localization studies of all of the angiopoietins in mouse and human. The structural divergence of angiopoietin-3 and angiopoietin-4 appears to underlie diverging functions of these counterparts. Angiopoietin-3 and angiopoietin-4 have very different distributions in their respective species, and angiopoietin-3 appears to act as an antagonist, whereas angiopoietin-4 appears to function as an agonist. 
653 |a research-article 
653 |a Biochemistry 
700 1 |a Griffiths, Jennifer A.  |e verfasserin  |4 aut 
700 1 |a Rojas, Jose  |e verfasserin  |4 aut 
700 1 |a Aldrich, Thomas H.  |e verfasserin  |4 aut 
700 1 |a Jones, Pamela F.  |e verfasserin  |4 aut 
700 1 |a Zhou, Hao  |e verfasserin  |4 aut 
700 1 |a McClain, Joyce  |e verfasserin  |4 aut 
700 1 |a Copeland, Neal G.  |e verfasserin  |4 aut 
700 1 |a Gilbert, Debra J.  |e verfasserin  |4 aut 
700 1 |a Jenkins, Nancy A.  |e verfasserin  |4 aut 
700 1 |a Huang, Tammy  |e verfasserin  |4 aut 
700 1 |a Papadopoulos, Nick  |e verfasserin  |4 aut 
700 1 |a Maisonpierre, Peter C.  |e verfasserin  |4 aut 
700 1 |a Davis, Samuel  |e verfasserin  |4 aut 
700 1 |a Yancopoulos, George D.  |e verfasserin  |4 aut 
773 0 8 |i in  |t Proceedings of the National Academy of Sciences of the United States of America  |d Washington, DC : National Acad. of Sciences  |g Vol. 96, No. 5 (1999), p. 1904-1909  |q 96:5<1904-1909  |w (DE-601)JST069399220  |x 0027-8424 
856 4 1 |u https://www.jstor.org/stable/46986  |3 Volltext 
912 |a GBV_JSTOR 
951 |a AR 
952 |d 96  |j 1999  |e 5  |h 1904-1909 

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