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Protein Kinase C Phosphorylation Sensitizes but Does Not Activate the Capsaicin Receptor Transient Receptor Potential Vanilloid 1 (TRPV1)

Protein kinase C (PKC) modulates the function of the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the channel is activated by capsaicin. In addition, studies have suggested that phosphorylation by PKC might directly gate... Full description

1st Person: Bhave, Gautam
Additional Persons: Hu, Hui-Juan; Glauner, Kathi S.; Zhu, Weiguo; Wang, Haibin; Brasier, D. J.; Oxford, Gerry S.; Gereau, Robert W.
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 100, No. 21 (2003), p. 12480-12485
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Type of Publication: Article
Language: English
Published: 2003
Keywords: Neuroscience
Online: Volltext
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