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A Receptor Tyrosine Kinase cDNA Isolated from a Population of Enriched Primitive Hematopoietic Cells and Exhibiting Close Genetic Linkage to C-kit

We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells. Sequence analysis of this clone reveals strong homology to the c-Kit subfamily of receptor kinases, and in particular to the... Full description

1st Person: Matthews, William
Additional Persons: Jordan, Craig T. verfasserin; Gavin, Marc verfasserin; Jenkins, Nancy A. verfasserin; Copeland, Neal G. verfasserin; Lemischka, Ihor R. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 88, No. 20 (1991), p. 9026-9030
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Type of Publication: Article
Language: English
Published: 1991
Keywords: research-article
Biochemistry
Hematopoietic Stem Cell
Protein-Tyrosine Kinase
Online: Volltext
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