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Cancer Regression and Autoimmunity Induced by Cytotoxic T Lymphocyte-Associated Antigen 4 Blockade in Patients with Metastatic Melanoma

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical immunoregulatory molecule (expressed on activated T cells and a subset of regulatory T cells) capable of down-regulating T cell activation. Blockade of CTLA-4 has been shown in animal models to improve the effectiveness of cancer... Full description

1st Person: Phan, Giao Q.
Additional Persons: Yang, James C. verfasserin; Sherry, Richard M. verfasserin; Hwu, Patrick verfasserin; Topalian, Suzanne L. verfasserin; Schwartzentruber, Douglas J. verfasserin; Restifo, Nicholas P. verfasserin; Haworth, Leah R. verfasserin; Seipp, Claudia A. verfasserin; Freezer, Linda J. verfasserin; Morton, Kathleen E. verfasserin; Mavroukakis, Sharon A. verfasserin; Duray, Paul H. verfasserin; Steinberg, Seth M. verfasserin; Allison, James P. verfasserin; Davis, Thomas A. verfasserin; Rosenberg, Steven A. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 100, No. 14 (2003), p. 8372-8377
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Type of Publication: Article
Language: English
Published: 2003
Keywords: research-article
Online: Volltext
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