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Antitumor Activity and Pharmacokinetics of a Mixed-Backbone Antisense Oligonucleotide Targeted to the RIα Subunit of Protein Kinase A after Oral Administration

Overexpression of the RIα subunit of cAMP-dependent protein kinase (PKA) has been demonstrated in various human cancers. PKA has been suggested as a potential target for cancer therapy. The goal of the present study was to evaluate an anti-PKA antisense oligonucleotide (mixed-backbone... Full description

1st Person: Wang, Hui
Additional Persons: Cai, Qiuyin verfasserin; Zeng, Xiaofei verfasserin; Yu, Dong verfasserin; Agrawal, Sudhir verfasserin; Zhang, Ruiwen verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 96, No. 24 (1999), p. 13989-13994
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Type of Publication: Article
Language: English
Published: 1999
Keywords: research-article
Medical Sciences
Online: Volltext
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