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Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs

Evidence of endoplasmic reticulum (ER) stress has been found in lungs of patients with familial and sporadic idiopathic pulmonary fibrosis. We tested whether ER stress causes or exacerbates lung fibrosis by (i) conditional expression of a mutant form of surfactant protein C (L188Q SFTPC) found in... Full description

1st Person: Lawson, William E.
Additional Persons: Cheng, Dong-Sheng; Degryse, Amber L.; Tanjore, Harikrishna; Polosukhin, Vasiliy V.; Xu, Xiaochuan C.; Newcomb, Dawn C.; Jones, Brittany R.; Roldan, Juan; Lane, Kirk B.; Morrisey, Edward E.; Beers, Michael F.; Yull, Fiona E.; Blackwell, Timothy S.
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 108, No. 26 (2011), p. 10562-10567
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Type of Publication: Article
Language: English
Published: 2011
Online: Volltext
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