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Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

Hyperphosphorylated tau plays an important role in the formation of neurofibrillary tangles in brains of patients with Alzheimer's disease (AD) and related tauopathies and is a crucial factor in the pathogenesis of these disorders. Though diverse kinases have been implicated in tau... Full description

1st Person: Kickstein, Eva
Additional Persons: Krauss, Sybille verfasserin; Thornhill, Paul verfasserin; Rutschow, Désirée verfasserin; Zeller, Raphael verfasserin; Sharkey, John verfasserin; Williamson, Ritchie verfasserin; Fuchs, Melanie verfasserin; Köhler, Andrea verfasserin; Glossmann, Hartmut verfasserin; Schneider, Rainer verfasserin; Sutherland, Calum verfasserin; Schweiger, Susann verfasserin; Südhof, Thomas C. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 107, No. 50 (2010), p. 21830-21835
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Type of Publication: Article
Language: English
Published: 2010
Keywords: research-article
Online: Volltext
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