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DNA End-Joining Catalyzed by Human Cell-Free Extracts

Mammalian cells defective in DNA end-joining are highly sensitive to ionizing radiation and are immunodeficient because of a failure to complete V(D)J recombination. By using cell-free extracts prepared from human lymphoblastoid cell lines, an in vitro system for end-joining has been developed.... Full description

1st Person: Baumann, Peter
Additional Persons: West, Stephen C. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 95, No. 24 (1998), p. 14066-14070
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Type of Publication: Article
Language: English
Published: 1998
Keywords: research-article
Biochemistry
DNA repair
Recombination
Ku protein
DNA-PK
DNA ligase
Online: Volltext
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