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Obese Gene Expression: Reduction by Fasting and Stimulation by Insulin and Glucose in Lean Mice, and Persistent Elevation in Acquired (Diet-Induced) and Genetic (Yellow Agouti) Obesity

Mutations in the obese (ob) gene lead to obesity. This gene has been recently cloned, but the factors regulating its expression have not been elucidated. To address the regulation of the ob gene with regard to body weight and nutritional factors, Northern blot analysis was used to assess ob mRNA... Full description

1st Person: Mizuno, Tooru M.
Additional Persons: Bergen, Hugo verfasserin; Funabashi, Toshiya verfasserin; Kleopoulos, Steven P. verfasserin; Zhong, You-Gong verfasserin; Bauman, William A. verfasserin; Mobbs, Charles V. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 93, No. 8 (1996), p. 3434-3438
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Type of Publication: Article
Language: English
Published: 1996
Keywords: research-article
Physiology
Leptin
mRNA
Hyperinsulinemia
Hyperglycemia
Diabetes
Online: Volltext
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