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Topical Vitamin D3 and Low-Calcemic Analogs Induce Thymic Stromal Lymphopoietin in Mouse Keratinocytes and Trigger an Atopic Dermatitis

We have demonstrated that cytokine thymic stromal lymphopoietin (TSLP), whose expression is rapidly induced upon keratinocyteselective ablation of retinoid X receptors (RXRs) -α and -β in the mouse ($RXR\alpha\beta^{ep-/-} mice$), plays a key role in initiating a skin and systemic atopic... Full description

1st Person: Li, Mei
Additional Persons: Hener, Pierre verfasserin; Zhang, Zhikun verfasserin; Kato, Shigeaki verfasserin; Metzger, Daniel verfasserin; Chambon, Pierre verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 103, No. 31 (2006), p. 11736-11741
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Type of Publication: Article
Language: English
Published: 2006
Keywords: research-article
retinoic acid
vitamin D receptor
retinoid X receptor
retinoic acid receptor
Online: Volltext
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