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An AAV-Derived Apaf-1 Dominant Negative Inhibitor Prevents MPTP Toxicity as Antiapoptotic Gene Therapy for Parkinson's Disease

Adeno-associated virus (AAV) vector delivery of an Apaf-1-dominant negative inhibitor was tested for its antiapoptotic effect on degenerating nigrostriatal neurons in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease. The wild-type caspase recruitment domain of... Full description

1st Person: Mochizuki, Hideki
Additional Persons: Hayakawa, Hideki verfasserin; Migita, Makoto verfasserin; Shibata, Mamoru verfasserin; Tanaka, Ryota verfasserin; Suzuki, Asuka verfasserin; Shimo-Nakanishi, Yumi verfasserin; Urabe, Takao verfasserin; Yamada, Masanori verfasserin; Tamayose, Kenji verfasserin; Shimada, Takashi verfasserin; Miura, Masayuki verfasserin; Mizuno, Yoshikuni verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 98, No. 19 (2001), p. 10918-10923
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Type of Publication: Article
Language: English
Published: 2001
Keywords: research-article
Neurobiology
Online: Volltext
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