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Chimeric Double-Stranded RNA-Specific Adenosine Deaminase ADAR1 Proteins Reveal Functional Selectivity of Double-Stranded RNA-Binding Domains from ADAR1 and Protein Kinase PKR

The RNA-specific adenosine deaminase (ADAR1) and the RNA-dependent protein kinase (PKR) are both interferon-inducible double-stranded (ds) RNA-binding proteins. ADAR1, an RNA editing enzyme that converts adenosine to inosine, possesses three copies of a dsRNA-binding motif (dsRBM). PKR, a... Full description

1st Person: Liu, Yong
Additional Persons: Lei, Ming; Samuel, Charles E.
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 97, No. 23 (2000), p. 12541-12546
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Type of Publication: Article
Language: English
Published: 2000
Keywords: Biochemistry
Online: Volltext
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