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Cell Fate Decision Mediated by p53 Pulses

The tumor suppressor p53 plays a crucial role in cellular response to various stresses. Recent experiments have shown that p53 level exhibits a series of pulses after DNA damage caused by ionizing radiation (IR). However, how the p53 pulses govern cell survival and death remains unclear. Here, we... Full description

1st Person: Zhang, Xiao-Peng
Additional Persons: Liu, Feng verfasserin; Cheng, Zhang verfasserin; Wang, Wei verfasserin; Wolynes, Peter G. verfasserin
Source: in Proceedings of the National Academy of Sciences of the United States of America Vol. 106, No. 30 (2009), p. 12245-12250
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Type of Publication: Article
Language: English
Published: 2009
Keywords: research-article
p53 network
DNA repair
apoptosis
variability
Online: Volltext
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