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High-Level Viremia in Adults and Children Infected with Human Immunodeficiency Virus: Relation to Disease Stage and CD4⁺ Lymphocyte Levels

Sixty-eight adults and nine children infected with human immunodeficiency virus type 1 (HIV-1) were evaluated consecutively for the presence and amount of cell-free infectious virus in their plasma. Viremia was detected in 18 of 68 adults and in five of nine children; titers ranged from 10 to... Full description

1st Person: Saag, Michael S.
Additional Persons: Crain, Marilyn J.; Decker, W. Don; Campbell-Hill, Sherri; Robinson, Susan; Brown, William E.; Leuther, Michael; Whitley, Richard J.; Hahn, Beatrice H.; Shaw, George M.
Source: in The Journal of Infectious Diseases Vol. 164, No. 1 (1991), p. 72-80
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Type of Publication: Article
Language: English
Published: 1991
Online: Volltext
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100 1 |a Saag, Michael S. 
245 1 0 |a High-Level Viremia in Adults and Children Infected with Human Immunodeficiency Virus: Relation to Disease Stage and CD4⁺ Lymphocyte Levels  |h Elektronische Ressource 
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500 |a Copyright: Copyright 1991 The University of Chicago 
520 |a Sixty-eight adults and nine children infected with human immunodeficiency virus type 1 (HIV-1) were evaluated consecutively for the presence and amount of cell-free infectious virus in their plasma. Viremia was detected in 18 of 68 adults and in five of nine children; titers ranged from 10 to 100,000,000 TCID/ml plasma. Among the adults, none of 19 asymptomatic patients, 4 of 34 AIDS-related complex patients, and 14 of 15 AIDS patients had cell-free infectious virus in their plasma. None of 35 adult subjects with CD4⁺ lymphocyte counts >400/mm³ were viremic, whereas 3 of 17 with 200-400 CD4⁺ lymphocytes/mm³ and 15 of 16 individuals with <200 CD4⁺ lymphocytes/mm³ were plasma viremic. In contrast to adults, each of five children infected with HIV-1 in utero or during the perinatal period were plasma viremic regardless of their CD4⁺ lymphocyte counts (range, 42-2227/mm³), duration of infection, or clinical stage; however, children infected by HIV-1 at older ages were less frequently plasma viremic. Therapy with zidovudine led to a 10- to 10⁶-fold decline in plasma HIV-1 TCID in all eight subjects studied before and after treatment. 
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700 1 |a Crain, Marilyn J. 
700 1 |a Decker, W. Don 
700 1 |a Campbell-Hill, Sherri 
700 1 |a Robinson, Susan 
700 1 |a Brown, William E. 
700 1 |a Leuther, Michael 
700 1 |a Whitley, Richard J. 
700 1 |a Hahn, Beatrice H. 
700 1 |a Shaw, George M. 
773 0 8 |i in  |t The Journal of Infectious Diseases  |g Vol. 164, No. 1 (1991), p. 72-80  |q 164:1<72-80  |w (DE-601)JST048837814  |x 0022-1899 
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952 |d 164  |j 1991  |e 1  |h 72-80 

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