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High-Level Viremia in Adults and Children Infected with Human Immunodeficiency Virus: Relation to Disease Stage and CD4⁺ Lymphocyte Levels

Sixty-eight adults and nine children infected with human immunodeficiency virus type 1 (HIV-1) were evaluated consecutively for the presence and amount of cell-free infectious virus in their plasma. Viremia was detected in 18 of 68 adults and in five of nine children; titers ranged from 10 to... Full description

1st Person: Saag, Michael S.
Additional Persons: Crain, Marilyn J.; Decker, W. Don; Campbell-Hill, Sherri; Robinson, Susan; Brown, William E.; Leuther, Michael; Whitley, Richard J.; Hahn, Beatrice H.; Shaw, George M.
Source: in The Journal of Infectious Diseases Vol. 164, No. 1 (1991), p. 72-80
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Type of Publication: Article
Language: English
Published: 1991
Online: Volltext
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Summary: Sixty-eight adults and nine children infected with human immunodeficiency virus type 1 (HIV-1) were evaluated consecutively for the presence and amount of cell-free infectious virus in their plasma. Viremia was detected in 18 of 68 adults and in five of nine children; titers ranged from 10 to 100,000,000 TCID/ml plasma. Among the adults, none of 19 asymptomatic patients, 4 of 34 AIDS-related complex patients, and 14 of 15 AIDS patients had cell-free infectious virus in their plasma. None of 35 adult subjects with CD4⁺ lymphocyte counts >400/mm³ were viremic, whereas 3 of 17 with 200-400 CD4⁺ lymphocytes/mm³ and 15 of 16 individuals with <200 CD4⁺ lymphocytes/mm³ were plasma viremic. In contrast to adults, each of five children infected with HIV-1 in utero or during the perinatal period were plasma viremic regardless of their CD4⁺ lymphocyte counts (range, 42-2227/mm³), duration of infection, or clinical stage; however, children infected by HIV-1 at older ages were less frequently plasma viremic. Therapy with zidovudine led to a 10- to 10⁶-fold decline in plasma HIV-1 TCID in all eight subjects studied before and after treatment.
Item Description: Copyright: Copyright 1991 The University of Chicago
Physical Description: Online-Ressource
ISSN: 0022-1899

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