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Deficient Responses of Pulmonary Macrophages from Healthy Smokers to Antiviral Lymphokines in vitro

The antiviral function of pulmonary macrophages obtained by broncholavage of healthy smokers and nonsmokers was studied. Compared with nonsmokers' cells, smokers' macrophages produced significantly more virus during in vitro infection with herpes simplex virus type 1 (HSV-1). Exposure of... Full description

1st Person: Rose, Richard M. verfasserin
Additional Persons: Wasserman, Andrew S. verfasserin; Weiser, Weishui Y. verfasserin; Remold, Heinz G. verfasserin
Source: in The Journal of Infectious Diseases Vol. 154, No. 4 (1986), p. 611-618
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Type of Publication: Article
Language: English
Published: 1986
Keywords: research-article
Online: Volltext
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100 1 |a Rose, Richard M.  |e verfasserin  |4 aut 
245 1 0 |a Deficient Responses of Pulmonary Macrophages from Healthy Smokers to Antiviral Lymphokines in vitro  |h Elektronische Ressource 
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500 |a Copyright: Copyright 1986 The University of Chicago 
520 |a The antiviral function of pulmonary macrophages obtained by broncholavage of healthy smokers and nonsmokers was studied. Compared with nonsmokers' cells, smokers' macrophages produced significantly more virus during in vitro infection with herpes simplex virus type 1 (HSV-1). Exposure of macrophages to either antiviral macrophage-activating factor or interferon-γ for 20 hr before infection resulted in diminished production of HSV-1 by both types of macrophages. However, in contrast to smokers' cells, exposure of nonsmokers' macrophages to these antiviral lymphokines totally prevented viral replication. This difference could not be attributed to diminished adsorption of virus to smokers' macrophages or to an increased proportion of extracellular to intracellular virus in smokers' cell cultures. The effect of smoking on viral infectivity did not appear to be mediated by secretion of a soluble factor by the macrophage because incubation of nonsmokers' cells with supernatant from smokers' cell cultures did not affect the growth of HSV-1. 
653 |a research-article 
700 1 |a Wasserman, Andrew S.  |e verfasserin  |4 aut 
700 1 |a Weiser, Weishui Y.  |e verfasserin  |4 aut 
700 1 |a Remold, Heinz G.  |e verfasserin  |4 aut 
773 0 8 |i in  |t The Journal of Infectious Diseases  |g Vol. 154, No. 4 (1986), p. 611-618  |q 154:4<611-618  |w (DE-601)JST048837814  |x 0022-1899 
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952 |d 154  |j 1986  |e 4  |h 611-618 

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