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Ephrin-A5 Induces Collapse of Growth Cones by Activating Rho and Rho Kinase

The ephrins, ligands of Eph receptor tyrosine kinases, have been shown to act as repulsive guidance molecules and to induce collapse of neuronal growth cones. For the first time, we show that the ephrin-A5 collapse is mediated by activation of the small GTPase Rho and its downstream effector Rho... Full description

1st Person: Wahl, Siegfried
Additional Persons: Barth, Holger verfasserin; Ciossek, Thomas verfasserin; Aktories, Klaus verfasserin; Mueller, Bernhard K. verfasserin
Source: in The journal of cell biology : JCB Vol. 149, No. 2 (2000), p. 263-270
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Type of Publication: Article
Language: English
Published: 2000
Keywords: research-article
Retinotectal
Repulsive
Eph receptor
Axon guidance
Collapse assay
Online: Volltext
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