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Removal of the Membrane-Anchoring Domain of Epidermal Growth Factor Leads to Intracrine Signaling and Disruption of Mammary Epithelial Cell Organization

Autocrine EGF-receptor (EGFR) ligands are normally made as membrane-anchored precursors that are proteolytically processed to yield mature, soluble peptides. To explore the function of the membrane-anchoring domain of EGF, we expressed artificial EGF genes either with or without this structure in... Full description

1st Person: Wiley, H. Steven
Additional Persons: Woolf, Margaret F. verfasserin; Opresko, Lee K. verfasserin; Burke, Patrick M. verfasserin; Will, Birgit verfasserin; Morgan, Jeffrey R. verfasserin; Lauffenburger, Douglas A. verfasserin
Source: in The journal of cell biology : JCB Vol. 143, No. 5 (1998), p. 1317-1328
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Type of Publication: Article
Language: English
Published: 1998
Keywords: research-article
Epidermal growth factor
Autocrine
Intracrine
Receptors
Epithelium
Online: Volltext
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