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Loss of APC Induces Polyploidy as a Result of a Combination of Defects in Mitosis and Apoptosis

Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene initiate a majority of colorectal cancers. Acquisition of chromosomal instability is an early event in these tumors. We provide evidence that the loss of APC leads to a partial loss of interkinetochore tension at metaphase... Full description

1st Person: Dikovskaya, Dina
Additional Persons: Schiffmann, David verfasserin; Newton, Ian P. verfasserin; Oakley, Abigail verfasserin; Kroboth, Karin verfasserin; Sansom, Owen verfasserin; Jamieson, Thomas J. verfasserin; Meniel, Valerie verfasserin; Clarke, Alan verfasserin; Näthke, Inke S. verfasserin
Source: in The journal of cell biology : JCB Vol. 176, No. 2 (2007), p. 183-195
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Type of Publication: Article
Language: English
Published: 2007
Keywords: research-article
Online: Volltext
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